Alpha Brain Vs Lion's Mane Mushroom

Alpha Brain and Lion's Mane are two very popular Nootropic Supplements. But who do they benefit, and what are their differences?
Lions Mane VS Alpha Brain
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Lion's Mane and Alpha Brain are supplements often associated with cognitive enhancement.

TLDR: The main difference between Alpha Brain and Lion's Mane is their composition Lion's Mane is a singular extract from a naturally occurring mushroom, while Alpha Brain is a formulated nootropic stack developed by Onnit Labs with various ingredients.

Both are popular in the nootropic community for their potential cognitive-enhancing properties, emphasizing natural ingredients, and are available over-the-counter.

However, their scientific backing and side effects differ, with Lion's Mane having a longer history in traditional medicine and Alpha Brain having mixed research outcomes.

Summary Comparison Table

Aspect Lion's Mane Alpha Brain
Ingredients Mushroom (Hericium erinaceus) extract Blend of L-Theanine, L-Tyrosine, Oat Straw, Bacopa Monnieri, etc.
Origin and History Traditional Chinese medicine Developed by Onnit Labs
Primary Function Neuroprotective effects, stimulates nerve growth factor (NGF) Enhance cognitive function, memory, and concentration
Scientific Research Benefits for cognitive health, especially in preventing neurodegenerative diseases Mixed evidence; some studies support its efficacy, others do not
Side Effects Itchy skin rash for some Headaches, lucid dreaming, digestive upset
Cost About $14-16 per pound Around $80 for a one month supply
Time to See Results Effects felt within a few weeks for some Improvements noticed within a few days for some
Combining Supplements No known harmful interaction, but consult a healthcare professional before combining.



Lion's Mane primarily consists of the mushroom (Hericium erinaceus) extract, making it a singular ingredient supplement. In contrast, Alpha Brain is a nootropic stack containing a combination of various ingredients, including L-Theanine, L-Tyrosine, Oat Straw, and Bacopa Monnieri, among others.

Origin and History:

Lion's Mane has its roots in traditional Chinese medicine, where it has been revered for centuries for its potential health benefits. On the other hand, Alpha Brain is a modern concoction developed by Onnit Labs to cater to the growing demand for cognitive enhancers.

Primary Function:

Lion's Mane is known for its neuroprotective effects and its potential to stimulate the production of nerve growth factor (NGF). Meanwhile, Alpha Brain is specifically designed to enhance cognitive function, memory, and concentration, offering a multi-faceted approach to brain health.

Scientific Research:

Several studies on Lion's Mane indicate its potential benefits for cognitive health, especially in preventing neurodegenerative diseases. In contrast, the scientific evidence for Alpha Brain is mixed; while Onnit Labs claims its efficacy in cognitive function enhancement, some studies support these claims, and others do not.

Side Effects:

While Lion's Mane is generally considered safe, some individuals might experience an itchy skin rash after consumption. Alpha Brain, with its blend of ingredients, has potential side effects that include headaches, lucid dreaming, and digestive upset.


Cognitive Enhancement:

Both Lion's Mane and Alpha Brain are marketed and popularly used for their potential cognitive-enhancing properties, with many users reporting improved focus and memory. Lions mane is renound for being one of the best Nootropic mushrooms about.

Natural Ingredients:

Emphasizing the power of nature, both supplements prioritize the use of natural ingredients. Lion's Mane, being a natural mushroom, stands testament to ancient wisdom, while Alpha Brain combines several natural extracts for a holistic approach.


Their popularity in the nootropic community is undeniable. Both are frequently discussed in forums related to brain health and cognitive enhancement, with users sharing their experiences and results. Alpha brain became popular after being mention by Joe Rogan.


In general, both supplements are considered safe for consumption. However, as with any supplement, it's always recommended to consult with a healthcare professional before starting a regimen.

What are the main ingredients in Lion's Mane and Alpha Brain?

Lion's Mane is primarily composed of the extract from the Hericium erinaceus mushroom. In contrast, Alpha Brain is a blend of various ingredients, including L-Theanine, L-Tyrosine, Oat Straw, Bacopa Monnieri, and several others.

How do the costs of Lion's Mane and Alpha Brain compare?

Lion's mane mushrooms (Hericium erinaceus) are currently available fresh in US retail markets for about $14-16 per pound, whilst Alpha Brain costs around $80 for a one month supply. However, it's essential to consider the dosage, quality, and source when comparing costs.

How long does it take to see results with Lion's Mane and Alpha Brain?

The time to see results can vary for individuals. Some users report feeling the effects of Lion's Mane within a few weeks, while others the kick in time might take longer. For Alpha Brain, some users notice improvements in cognitive function within a few days, but consistent use over weeks might be required for more pronounced effects.

Can I take both Lion's Mane and Alpha Brain together?

While there's no known harmful interaction between Lion's Mane and Alpha Brain, it's essential to start with a lower dosage if combined and monitor for any adverse reactions. Consulting with a healthcare professional before combining supplements is always recommended.

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About the author
Thomas Riley

Thomas Riley

Thomas, a biohacker with a BSc (Hons) from Teesside University, shares insights passion and expertise on longevity, nootropics, and biohacking, catering to all levels of interest.


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